Natamycin (Pimaricin)
Natamycin (E235) is an antifungal compound used mainly in dairy and other foods to control yeast and mold. It is effective in surface treatments, typically preserves sensory quality, and is compatible with maturation processes.
Where is it used?
- Dairy: cheese surface treatments
- Meat: sausage & deli surface protection
- Bakery: tortilla/dough surface
- Beverages/sauces: yeast control (formulation-dependent)
Key benefits
- Helps reduce mycotoxin risk
- Extends/preserves shelf life (mold/yeast control)
- Designed for minimal sensory impact
- Typically does not inhibit starter cultures
Mode of action
Natamycin binds to sterols (mainly ergosterol) in fungal cell membranes and helps stop growth (fungistatic). It differs from some preservatives (e.g., sorbates/benzoates) that act via membrane permeabilization.
- Targets molds/yeasts; not intended for bacteria
- Highest impact in surface applications
- Limited penetration into product (≤5 mm)
Solubility & pH note
Natamycin has low solubility in water; suspension-based surface use is common. At pH>9 or pH<3 solubility may increase, but antifungal activity can be affected.
Composition
Natamycin Specifications
Storage & Shelf life
- Storage: Unopened packs below 20°C, dry, away from direct sunlight.
- Shelf life: 2 years under recommended conditions.
Application methods
- Spray: Apply as suspension onto surface
- Dipping: 2–4 min dip (common for cheese)
- Coating: Add into rind/coating systems
- Brine: Dose into brine (requires process control)
- Mix suspension well for uniform crystal distribution
- Adding 8–10% NaCl may help manage microbial load
- Regulatory limits vary by country